Cambridge Fighting Covid
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Can social distancing improve the trade-off between health and the economy?”
Update #10
Professor Giancarlo Corsetti
Faculty of Economics, University of Cambridge
Latest news
Sharing our updated pre-print on Delta Variant and emergence, replication and immune evasion properties. We previously reported partial evasion of neutralising antibody responses following vaccination and breakthrough in vaccinated health care workers.
SARS-CoV-2 B.1.617.2 Delta variant emergence, replication and immune evasion
The SARS-CoV-2 B.1.617.2 (Delta) variant was first identified in the state of Maharashtra in late 2020 and has spr...
www.biorxiv.org
Nice to have been able to contribute to an excellent discussion at a pivotal point in road to recovery . It will take longer than we expected even with vaccines https://twitter.com/IndependentSage/status/1395719004245823489
This week’s briefing is now live with special guest @GuptaR_lab discussing variants of concern with our experts. Presented by @theAliceRoberts & quick numbers update from @chrischirp. Join us. https://www.pscp.tv/w/c3ZOPDFNV0V3TGxMek53UWJ8MUJSS2pCcXlNT1pLd99NxIEwUssFi9iaI8l4_SiHatqVIG2DYr63fKfYpndc
➡️ ‘Like HIV, SARS-CoV-2 Can Cause Long Term Infections’
➡️ Prof. @GuptaR_lab @ravgup33_ravi @cam_fight_covid @Cambridge_Uni @HomertonCollege
➡️ With @s_jkr
➡️ 🎧 to the full #podcast on any of 9 platforms
➡️ #SoundCloud ▶️ https://soundcloud.com/user-617034707/like-hiv-sars-can-cause-long-term-infections
➡️ ▶️ https://anchor.fm/stratnews-global/episodes/Like-HIV--SARS-Can-Cause-Long-Term-Infections-evsudr
Single-cell #transcriptomics and #proteomics profiling of #COVID19 samples reveals immune and HSPC changes that are differentially associated with disease severity @HaniffaLab @ClatworthyLab @MarioniLab @UniofNewcastle @sangerinstitute @humancellatlas
Single-cell multi-omics analysis of the immune response in COVID-19
Transcriptomic and proteomic profiling of blood samples from individuals with COVID-19 reveals immune cell and hematopoi...
go.nature.com
Huge thanks to the team involved @CovidGenomicsUK @CUH_NHS @igoodfel @RealMcCoyLab @CambridgeBRC @cam_fight_covid @Cambridge_Uni https://twitter.com/GuptaR_lab/status/1337373686874198016
The first evidence of in vivo SARS-CoV-2 escape from antibodies: emergent Spike deletion H69/V70 and D796H mutation in a convalescent plasma (CP) treated patient. These mutations conferred reduced susceptibility to the CP and sera from multiple donors. https://www.medrxiv.org/content/10.1101/2020.12.05.20241927v1
This point is vital. These vaccines were possible due to investment in science. https://twitter.com/maxgabgut/status/1336402246955905024
Can we all scientists use this day to make sure everyone understands how important is long-term basic research funding? Government-funded science laid the groundwork for this vaccine. Loud and clear please. https://www.bbc.co.uk/news/uk-55227325
Cautious but good news on the first efficacy data for a COVID-19 vaccine. Can expect more news on other COVID vaccines shortly. It will then be about how they are used but a safe 90% efficacious vaccine is a game changer.
Best wishes to my clinical PhD student Ben Warne who has taken a short secondment to establish the Cambridge student testing scheme. Look forward to getting you back soon. https://twitter.com/OKaneCahir/status/1325046254771073025
P.S. If @Cambridge_Uni asymptomatic testing hadn’t shown relatively low & stable/declining infection rate among students, I’d have cancelled this class. Lesson: the lower we keep infections, the better we can do our daily business. @bealelab https://twitter.com/OKaneCahir/status/1324856275977592834
We find that many seriously ill Covid patients are coinfected with AMR pathogens so keep these in focus. This is where we work. https://twitter.com/takanocraig/status/1318830749030678529
This was one of the last @Cambridge_Uni institutes I visited before lockdown and the first I entered as we started to emerge. In the meantime, they had refocused almost all of their research on fighting #COVID19.
@CamBioCampus @Shorthand
https://www.cam.ac.uk/stories/citiid
Nobel Prize in Physiology or Medicine 2020 - Congratulations: A Year for Virologists @NobelPrize
The Nobel Prize in Physiology or Medicine 2020
The Nobel Prize in Physiology or Medicine 2020 was awarded jointly to Harvey J. Alter, Michael Houghton and Charle...
www.nobelprize.org
In 1984 at the dawn of HIV/AIDS, the Reagan administration claimed an effective vaccine would be available within 2 years. We are hearing similar claims for SARS-CoV-2/COVID-19. Virus escape mutations are inevitable and look at how fast D614G spread. Antiviral drugs = essential.
See the link below to my Blog on Manaus and herd immunity @ConversationUK. Also links into my previous essay on 'How we lost our collective memory of pandemics'
Coronavirus: is Manaus, Brazil, the first city to reach herd immunity?
Herd immunity has entered the everyday language, but it is a much misunderstood term.
theconversation.com
A plea to all: given seasonal cold viruses circulating please check PHE guidance before isolating and requesting COVID-19 testing.
* a new continuous cough
* a high temperature (38C or above)
* a loss of, or change in, your normal sense of taste or smell (anosmia).
Great news and a well deserved achievement. Looking forward to develop an exciting collaboration on Alpha-1 Antitrypsin deficiency. https://twitter.com/je_chambers/status/1305825012465664000
Thrilled to receive the ALTA award for basic research into Alpha-1-Antitrypsin deficiency from #Grifols. This will fund a collaboration between @TheCIMR ’s @MarciniakLab
and @SCICambridge’s @VallierLab, continuing our work on ER-biology in this disease. Can’t wait to get started!
Vaccine expert @GordonDougan1 guides us through the potential challenges of developing and delivering a #COVID19 vaccine.
https://www.cam.ac.uk/stories/covid19vaccine
@CamInfectDis @cam_fight_covid
A Cambridge hospital has piloted the use of combined PCR and antibody testing, after research by @GuptaR_lab from @cam_fight_covid showed that this approach was superior to virus detection alone for diagnosing #COVID19:
@CambridgeBRC @wellcome @CUH_NHS
Combining PCR and antibody tests at point of care dramatically
Point-of-care testing – in other words, testing patients as soon as they arrive at the hospital – is essential...
bit.ly
Pleased to share this work on accuracy of combined POC nucleic acid and antibody testing for COVID-19. Importantly POC serology tests are able to detect antibody responses to D614G
@CUH_NHS @PHE_uk @wellcometrust @AHRI_News @CMO_England @CovidGenomicsUK
Combined point of care nucleic acid and antibody testing for SARS-CoV-2 following emergence of D614G Spike Variant
Rapid COVID-19 diagnosis in hospital is essential, though complicated by 30-50% of nose/throat swabs being negative by...
www.cell.com
Our latest paper could help explain why age is major risk factor for dying from COVID-19, with people over 70 years at greatest risk, and why the disease can cause heart complications in severe cases. https://www.sciencedirect.com/science/article/pii/S0022282820302571 @Cambridge_Uni @Catz_Cambridge
Please share. We are looking for a computational biologist to join us: https://www.mrc-tox.cam.ac.uk/research/thaventhiran-project. They will be studying the most relevant system for world health concerns, working with unique datasets, bringing clonal definition to immuno- pathology and protection. https://twitter.com/MRC_TU/status/1293914181150707714
New vacancy at MRC Toxicology Unit: Research Assistant/Associate: Computational Immunology to develop novel methods for the categorisation of single-cell transcriptomic data at the level of the individual T or B lymphocyte clone. http://www.jobs.cam.ac.uk/job/26614/ #jobs #immunology